The effects of cisplatin are mediated through high levels of DNA damage, leading to programmed cell death or cell cycle arrest [6].
These results suggest that an anti-oestrogenic effect associated with pre-eclampsia may be mediated through high levels of α-foetoprotein rather than low levels of oestradiol.
We have hypothesized that the anti-oestrogenic effect of pre-eclampsia could be mediated through high intrauterine levels of AFP, rather than low levels of oestradiol.
Parathyroid hormone (PTH) signalling in osteoblasts leads to an increased number of HSCs, probably mediated through high expression levels of the Notch ligand Jagged1 in osteoblasts (Calvi et al., 2003).
1 The main causes of ischaemic heart disease have been well known for decades, and smoking, physical inactivity, and unhealthy diet (the last two partly mediated through high blood pressure, high cholesterol, overweight, and type 2 diabetes) can explain most new cases.
Consequently, the selection, introduction, and establishment of forestry species is often associated with traits linked to successful invasions: high propagule pressure, short generation times, high growth rates [ 9, 17], as well as high adaptability as mediated through high genetic diversity [ 4, 6, 8, 18, 19].
Specific leaf area declined from 187 in shade (reducing sunlight to 30%) to 109 cm2 g−1 in full sun without effect of N. Positive effects of nitrogen on growth and biomass production were mediated through higher radiation-use efficiency, RUE, ranging from 0.23 to 0.46 g MJ−1 (PAR).
Thus, favorable alterations in both skeletal muscle and adipose tissue mass and distribution mediated through high-intensity PRT can result in improvements in the metabolic health of individuals with type 2 diabetes.
However, LPA is only one member of a family of endogenous lipid-like substances endowed with a host of biological actions that are often mediated through high-affinity interactions with specific cell surface and intracellular proteins.
Presumably, the effect of the 24 kDa protein is mediated through higher order complex formation with wild-type p53 in p53+/m mice.
For example, it can be mediated through higher maternal investment in the offspring of fitter mothers or more attractive fathers [ 52, 53].
