Sentence examples for mediated secretion of from inspiring English sources

Co-treatment of the cells with IL-1α and IL-1RA or the COX-2 enzyme inhibitor NS398 abolished the IL-1α mediated secretion of PGE2.

In non-metastatic melanoma cells, ASC expression leads to decreased NF-κB activity and reduced tumorigenesis; however, ASC expression in metastatic melanoma cells increases NF-κB activity resulting in increased expression of pro-IL-1β, inflammasome mediated secretion of active IL-1β and enhances tumorigenesis (Liu et al., 2013).

This attenuation of H37Ra may be further compounded by a failure to moderate the host intracellular milieu via ESX-1 mediated secretion of effectors.

These sensors bind dsDNA, and associate with inflammasome adaptor molecules for caspase-1 mediated secretion of IL1β, which can indirectly stimulate the endothelium [14], [29].

Adaptive immunity includes lymphocyte mediated secretion of specific antibodies, while innate immune respones include secretion of non-antigen specific compounds.

Our findings suggested that TAMs participate in the metastasis of CRC induced by PRL-3 through the TNF-α mediated secretion of IL-6 and IL-8 in a paracrine manner.

Therefore, to elicit maximal antitumor responses, bacterial-mediated secretion of therapeutic factors without the requirement of bacterial lysis have been investigated in this study.

These findings also demonstrate for the first time that glia-mediated secretion of neurotrophins is a promising treatment that may be applicable to other neurodegenerative conditions.

To validate this result, we designed a novel method based on Caenorhabditis elegans cup5 ar465) mutants to specifically evaluate signal peptide-mediated secretion of nematodal proteins.

Fig. 5 Therapeutic effects in the immunocompetent BALB/c mice with highly aggressive tumors elicited by ST8-mediated secretion of Endostatin. a Potent treatment of large established tumors with ST8/pSEndo.

Hypoxia-mediated secretion of erythropoietin (EPO) from the kidney maintains erythrocyte mass through inhibition of apoptosis in bone marrow precursors.