Sentence examples for mediated by systemic from inspiring English sources

In heart failure, growth stimulation initially occurs as a compensatory effort to meet chronically altered hemodynamic demands and is mediated by systemic and/or local up-regulation of mediators of adrenergic pathways and by various cytokines [ 4, 5].

Our data revealed that the neuroprotective effect mediated by systemic administration (IP) of (S -roscovitine, the levogyre form of roS -roscovitinesimilar thethat obtained after ICV administration, showing that there is no levogyreneuroprotective eformt throfgh systemic administroscovitine

These associations may be mediated by systemic inflammation, the immune response to periodontal infection, or direct invasion by pathogens.

Decrease in MAP and HR caused by IV JM-1232 may be mediated by systemic vasodilation induced by blockade of sympathetic nerve activity and direct vasodilatory action.

This study provides no support for the beneficial effects of exercise on bone in the elderly being mediated by systemic or local muscle-derived effects rather than local adaptation to altered mechanical strain.

Authors of these investigations concluded that exercise can induce cardioprotection by triggering remote preconditioning and that this cardioprotection was at least partially mediated by systemic release of one or more humoral factors.

Here, we hypothesized that this decline is primarily due to cell non-autonomous (extrinsic) aging mediated by the systemic environment.

Among the proposed hypotheses are hypoxemia and/or hypoperfusion due to pulmonary dysfunction and circulatory depression [ 13] or damage mediated by a systemic inflammatory response induced by the pneumonitis [ 14].

Katayama fever is thought to be mediated by a systemic hypersensitivity reaction to migrating parasites and circulating immune complexes at the onset of egg production [ 4], leading to the classical clinical symptoms.

In the present study, we used data from a nationally representative sample to explore the association between 25(OH D and T2DM and HbA1c and test whether these associations were mediated by serum systemic inflammation.

The initial consensus definitions recognized two inciting pathways for ALI/ARDS: pulmonary and extrapulmonary - reflecting either direct lung injury or indirect injuries to the pulmonary endothelium as mediated by the systemic inflammatory response [ 20, 21].