Sentence examples for mediated by sequences from inspiring English sources

These data are consistent with a mechanism for MEOX2-driven induction of senescence that requires both DNA binding and transcriptional activation, mediated by sequences between a.a. 85 and 186, in addition to the homeodomain.

In protein interaction networks, the pairwise binding of proteins is directly mediated by sequences, and natural selection can act to maintain complementary sequences in two interacting proteins [ 45].

However, the N-Bak protein is not expressed in sympathetic neurons and this is due to translational repression mediated by sequences in the 5′- and 3′-UTRs of the N-Bak mRNA.

In addition, we have recently shown that the regulatory specificity of a myoblast homeodomain TF is mediated by sequences preferentially bound by that particular homeodomain and not by other related family members (Busser et al., 2012b).

We examined whether the interaction between NIPA1 and BMPRII is mediated by sequences on the cytoplasmic tail of BMPRII by transfecting full-length myc-BMPRII or myc-BMPRIIΔtail (Fig.  3G) into HeLa cells stably expressing NIPA1-GFP, and then immunoprecipitating as described earlier.

The overall implication is that cleavage specificity is mediated by sequence-dependent DNA deformations that influence the scissile phosphate positioning and reactivity.

MEDUSA is an algorithm that uses boosting to learn cis regulatory motifs and builds a gene regulatory program from promoter sequence and gene expression data, using the expression levels of known transcriptional regulators and signal transducers to help predict the differential expression of target genes as mediated by sequence motifs.

(These results are shown in Figure S5) Thus, rescue is not simply due to expression of an exogenous gene; it is mediated by sequence-specific features of Syn-IlvA-1.

As mentioned before, the individual phenotype is known to be shaped by phenomena that are or are not mediated by sequence variations in DNA, i.e. inheritance is both genetic and environmental, with the latter primarily relying on the quality of mother-infant interaction [52].

3) Upon induction mediated by sequence-specific DNA binding proteins, a much larger amount of P-TEFb is recruited to the locus, which can phosphorylate CSpt5 (and NELF) to remove the repressive effect, which in turn allows the phosphorylation of RNAPII CTD, thereby allowing assembly of additional accessory factors for productive elongation.

These results suggest that multiple MITE families may originate from a single ancestral autonomous element, and formation of MITEs can be mediated by sequence microhomology.