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Adaptation, i.e. the reversal of the effect of changes in the ligand concentration, is mediated by reversible receptor methylation and demethylation, catalysed by enzymes CheR and phosphorylated CheB (CheB-P), respectively.
Fibre dissolution in water leads to re-formation of nanoglobules, suggesting that this dynamic supramolecular assembly of mechanoresponsive protein-building blocks is mediated by reversible non-covalent interactions.
The adhesion of a cell to a surface is mediated by reversible bonds between specific receptor-ligand molecules [18].
Instead, our results support the hypothesis that acquired resistance to VEGFR antagonists is mechanistically distinct and at least partially mediated by reversible changes in gene expression patterns within the tumor cells and/or microenvironment.
This finding is consistent with other reports demonstrating that acquired resistance to VEGFR antagonists might, at least in part, be mediated by reversible changes.
Redox-sensitive regulation of HIF-1α transactivation has been described and proposed to be mediated by reversible oxidation of C800 in HIF-1α [ 13].
Similar(54)
Non-ionic poly N-acryloylmorpholine) (poly N-acryloylmorpholinene (PNAM -decoratedere synthesized by PNAM -decoratedinduced self-assembly (polystyreneulsion, mediated by the reversible addition-fragmentation chain transfer (RAFT) technique, in a one-PSt/two-steparticles.
The catalytic activity and sensitivity of this enzyme are mediated by a reversible phosphorylation [ 73].
The found changes indicate that the metabolic depression observed during the last winter of the lamprey's life cycle is mediated by prolonged reversible mitochondrial dysfunction.
Adaptation to stimuli, mediated by the reversible methylation of MCPs in the process catalyzed by CheR and CheB, allows cells to remain sensitive to small changes in chemoeffector concentration over a large range [ 7, 8].
In a number of short-tailed phages, adsorption is mediated by an initial reversible binding of the phage to bacterial LPS, followed by an irreversible attachment of the phage to an unknown secondary receptor, the presence of which has been found to be necessary for infection.
Related(15)
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