Sentence examples for mediated by mutant from inspiring English sources

The mechanism for invasion mediated by mutant MLK3 remains to be determined; nevertheless, a role for MLK3 in cell migration has been previously demonstrated (29).

45 It is therefore suggested that perturbation of TET2 function by 2-HG is a primary mechanism for oncogenesis mediated by mutant IDH1/2.

The ESCRT complex is also involved in the endosomal lysosomal degradation of neurotransmitter receptors (34, 35), so impairment of receptor homeostasis and excitotoxic insult is another potential neurotoxic mechanism that could be mediated by mutant CHMP2B proteins.

Transgenic mice and rats expressing a human gene for SOD1 with an ALS-linked mutation develop an ALS phenotype, whereas those with deletion of wild-type SOD1 do not, indicating that acquired toxicity mediated by mutant SOD1 is involved in neurodegeneration.

The difference between the 50  μ M novobiocin/efflux histogram and the FTC/efflux histogram was smallest for cells transfected with wild-type ABCG2, suggesting that novobiocin is more effective in inhibiting wild-type-mediated transport, as shown in Table 3. Efflux mediated by the mutant ABCG2 proteins was nearly unaffected by novobiocin.

Finally, { Mutant_UptakeRate(<=5)}{ UptakeRate Unit will return all experiments in which the rate of uptake mediated by the mutant transporter was ≤5% of that of the WT transporter.

Therefore, upregulation of osteogenic mediators in response to LPxF, LPxE or WSK, could be facilitated due to a weak inflammatory response mediated by these mutant LPS structures.

The pathogenic mechanism of DM1 and DM2 is thought to be mediated by the mutant RNA transcripts containing expanded CUG and CCUG repeats that have been associated with a toxic RNA gain of function.

Our generalized and more explicit model proposes that interconversions between the same two conformers identified here are responsible for the attractant signal from SRI M accumulation, the repellent response from SRI M photoactivation, the repellent response mediated by inverted mutant SRI−HtrI complexes, and the repellent responses mediated by the SRII−HtrII complex.

When added at the same time, a further ∼2-fold increase in repression mediated by the TRβΔAF2 mutant was observed.

However, until now little has been known about the normal function of LRRK2 or the pathogenic pathways mediated by PD-linked mutant LRRK2.