Sentence examples for mediated by mutations from inspiring English sources

However, a uniform distribution ignores experimental data, which have demonstrated a higher risk for cancer mediated by mutations if the same cumulative dose is taken over a shorter than a longer duration.

The other forms are mediated by mutations in the RET proto-oncogene and the NF1, SDHB, SDHC, or SDHD tumor suppressor genes.

Such tolerance is often mediated by mutations to chromosomal genes [32], with resistance in a number of aquatic bacterial species linked to changes in the genes coding for DNA gyrase and topoisomerase IV enzymes [22], [33] [34].

In 8 strains, resistance to isoniazid was not mediated by mutations in any of them.

The disease-gene association mediated by mutations can be more proper for exploring pathological mechanism of mutation induced diseases.

Resistance to cancer chemotherapy can be mediated by mutations in specific genes such as MDR1 (P-glykoprotein).

It is natural to assume that this functional divergence is mediated by mutation of certain amino acid positions.

CQ-hiR was previously generated in AS-30CQ of the P. chabaudi AS-lineage by drug selection over about 40 passages [ 17, 18], leading to the suggestion that the CQ-hiR phenotype arose by a series of small steps and was mediated by several mutations at different loci, although the number of mutations was not predicted.

Our data reveal that resistance in this patient was not mediated by acquired mutations or sub-clonal evolution under selection pressure exerted by treatment, but by a combination of pre-existing mutations in two genes that activate at least two pro-growth/pro-survival pathways.

In Plasmodium falciparum, resistance to folate inhibitors like pyrimethamine is mediated by point mutations in the target gene dihydrofolate reductase (dhfr).

We propose that further genomic studies should focus on the single-cell level, to better understand the aetiology of aging and diseases mediated by somatic mutations.