Sentence examples for mediated by excess from inspiring English sources

Recently it has been suggested that maternal endothelial cell dysfunction mediated by excess sFlt-1 is a major cause of the onset of the disease [22].

These results suggested that IL-18-MetS association might not be exclusively mediated by excess adiposity or associated biomarkers, and lean mass might also play a potential role.

CPT-11 associated intestinal damage is mediated by excess eicosanoid production (Kase et al, 1997; Sakai et al, 1995, 1997).

The adverse effect of psychosocial stressors on immune function is considered to be mediated by excess secretion of the stress hormone cortisol and the catecholamines [ 21, 22].

Our flotillin-1 overexpression experiments at least exclude that the anti-inflammatory effect of flotillin-1 shRNA was mediated by excess flotillin-2 exhibiting aberrant binding.

The aim of this study was to assess the associations between gestational diabetes, existing diabetes, glycosuria, adiposity, and a range of cardiometabolic risk factors (including measures of glucose and insulin metabolism) in offspring at age 15.5 years and to examine whether any associations are mediated by excess offspring adiposity.

If autophagy is inactivated by mTOR activation and AMPK and Sirt1 inactivation in obesity and diabetic renal diseases, autophagy deficiency could enhance organelle dysfunction mediated by nutrient excess, hypoxia, and proteinuria.

These changes are mediated by an excess of activity resulting from an increased expression of the active form of the proteases, and/or from an altered equilibrium between the proteases and their inhibitors in inflamed synovial membrane and synovial fluids (SF) [ 1- 4].

Alternatively, mounting evidence indicates that activation of JNK is central to the development of insulin resistance in response to obesity mediated by fatty acid excess, by phosphorylating IRS1 in serine (for a review, see 17).

One possible explanation is that the dose/response curve for leptin is intrinsically bathtub-shaped, with adverse effects mediated both by excess and by insufficient leptin stimulation.

Similarly, if dMCPH1-B degradation in Cdh1-supplemented Xenopus interphase egg extract were mediated by APCCdh1, addition of excess NT-Cyclin B should inhibit its degradation.