Sentence examples for mediated by exaggerated from inspiring English sources

Although evidence from clinical and non-clinical investigations suggests that emotional hyper-reactivity and altered cognitive control are mediated by exaggerated response in emotion brain regions and under recruitment of cognitive control regions, little is known about how anxiety influences emotion-cognition interactions [15].

Thus, it is possible that the generalized threat responses reported here are mediated by exaggerated responses in the CeA or other areas of the brain implicated in fear processing, many of which are innervated by midbrain dopamine neurons.

Two principal mechanisms have been suggested: vasculitis mediated by toxins and an exaggerated immune response in the host [ 11- 14].

Under healthy conditions TLR4 is only minimally expressed in lamina propria mononuclear cells (LPMNCs) and intestinal epithelial cells which are partly tolerant to LPS, thus preventing an exaggerated immune response mediated by the large number of bacteria in the intestinal lumen and maintaining a basal state of activation [ 10, 11].

Inflammatory synergy between C. albicans and S. aureus has recently been reported in an acute peritoneal model of infection, mediated by the cyclooxygenase pathway and induction of an exaggerated neutrophilic response (Peters and Noverr, 2013).

There is growing evidence that an exaggerated response to intestinal bacteria mediated by the NOD2/CARD15 (nucleotide-binding oligomerization domain protein 2/caspase recruitment domain 15) system in the inflammasome (associated with Crohn disease) leading to a nuclear factor-kappa-B overactivation may be involved in SAPHO syndrome [ 10].

The exaggerated increase in the NLR was mediated by the dramatic and more severe presence of lymphopenia following TKA.

Disease exacerbation is associated with exaggerated CNS inflammatory responses to systemic inflammation mediated by microglia that become 'primed' by the underlying neurodegeneration.

Such findings have lead to the hypothesis that only immunocompetent males should be able to "afford" high levels of testosterone, and hence that exaggerated sex-typical traits (which are proposed to be mediated by testosterone) should be an honest signal of heritable immunity to local pathogens (see Folstad and Karter 1992; Muehlenbein and Bribiescas 2005), and hence a "good genes" indicator.

As the chief oxidant in cells is H2O2, recent reports that IL-1β signaling in epithelial cells is mediated by H2O2 [10] support the notion that oxidant imbalances in CF cells would contribute to exaggerated inflammatory responses.

Overall, these studies suggest that the increased ROS levels leading to the exaggerated hypertrophic response with HKII knockdown and mitochondrial dissociation may be mediated by increased MPT.