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Resistance mediated by breast cancer resistance protein is similar to the pattern seen with P-gp-mediated chemoresistance.
A natural question that arises in this setting is the extent to which the effects of breast cancer risk factors are mediated by breast density and the extent to which such effects are through other pathways.
They point out that if breast density is to serve as a surrogate for breast cancer prevention in intervention trials, then most of the effect of such interventions on breast cancer risk should be mediated by breast density.
Stated another way, we may be interested in the extent to which the effect of traditional risk factors on breast cancer is mediated by breast density.
The methods could also be used to assess whether the effect of various traditional risk factors (genetic factors, age, weight, age at menarche, parity, hormone replacement therapy, and so forth) on breast cancer are mediated by breast density.
Similar(55)
Women of higher socioeconomic status (SES) are at increased risk of developing breast cancer, but it is unclear to what extent this is mediated by differences in mammographic breast density, a well-established breast cancer risk factor.
This supports our hypothesis that NDPK-mediated increases in extracellular ATP levels by breast tumour cells provide a mechanistic basis by which targeted therapeutics can prevent tumour growth and angiogenesis.
The need for a 43TRKN46 motif and for a GAG-mediated process in CCL5 secretion may enable the future design of modalities that prevent CCL5 release by breast tumor cells.
The study was designed to identify genetic variants that affect the risk of developing hormonally mediated (ie breast, ovarian and prostate) cancers.
Funded by Breast Cancer Campaign 2005Nov088).
Supported by Breast Cancer Campaign.
Related(19)
regulated by breast
mediated by lactation
mediated by cancer
mediated by tissue
mediated by maternal
mediated by mammary
mediated by search
mediated by television
mediated by endocytosis
mediated by someone
mediated by disaster
mediated by territoriality
mediated by glucose
mediated by phosphorylation
mediated by plasmodesmata
mediated by language
mediated by student
mediated by paper
mediated by technology
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