Sentence examples for mediated accumulation of from inspiring English sources

These changes are however different from what we observed during heat shock, and most importantly during conditioning (exposure to mild heat shock followed by recovery), when OPA1 cleavage is followed by PARL mediated accumulation of soluble OPA1.

A reduction in the colony-formation capacity was observed in resistant A2780 cells [ 6], and 4-HPR mediated accumulation of dhCer has been linked to cell cycle arrest [ 19].

Man A mediated accumulation of misfolded proteins also appears to be depended on the rate of cell division, since only rapidly dividing cancer cells appear to accumulate more ubiquitinated proteins than normal cells or LC3-deficient cancer cells.

However, in LNCaP human prostate carcinoma cells 1,25(OH)2D mediated accumulation of p21 mRNA appears to be indirect [ 10] through induction of IGF binding protein 3 (IGFBP-3) gene expression and suppression of IGF-1 signaling [ 11].

We also found an association between CTCF and RNAPII downstream of the included exons (regions w4 and w5) (CTCF localizing with RNAPII z-score = 10.20 and RNAPII localizing with CTCF z-score = 3.246), consistent with a CTCF mediated accumulation of RNAPII [ 23].

Those radiolabeled HPMA derivatives appear also to be suitable to investigate processes such as the EPR-mediated accumulation of nanoparticles in tumor tissue.

Redox reactions that occur with the participation of the oxidant can contribute to nano-SiO2-mediated accumulation of ·OH: 1. О2 − · + М n + → M(n − 1) + O2;   2.

More recent findings further demonstrated that salinity-induced rapid L pr down-regulation and redistribution of PIPs to internal compartments are controlled by the salicylic acid-mediated accumulation of reactive oxygen species (ROS), which is stimulated by salinity stress (Boursiac et al. [2008]).

In a cytotoxicity assay we show that bovine endothelial cells were more than 200 times more sensitive to melflufen than to melphalan, in HUVEC cells the difference was more than 30-fold and accompanied by aminopetidase-mediated accumulation of intracellular melphalan.

In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.

The lack of a measurable TLR4-mediated accumulation of leukocytes in response to B. parapertussis (Fig. 2) led us to assess whether or not B. parapertussis actively inhibits TLR4-mediated cytokine production.