Sentence examples for mediate the mitogenic from inspiring English sources

This receptor may mediate the mitogenic activity of alpha 2M in vSMC culture.

Activated ERKs, which are a type of MAP kinase, mediate the mitogenic and pro-inflammatory responses of insulin signaling.

However, PGE2 appeared to mediate the mitogenic effect of EGF in BALB/c 3 T3 cells, and of PDGF in Swiss 3 T3 cells [ 49, 50].

The following equations describe this core module: Another important collection of species is AP-1, which is used to denote a family of transcription factors that mediate the mitogenic signal F m.

ERα is thought to mediate the mitogenic actions of estrogen by inducing the expression of genes involved in cell proliferation, including cyclin D1, MYC and stromal cell-derived factor (SDF -1 [ 2, 3].

Thus, the involvement of Socs3a (this study) and STAT3 (Jin et al., 2008) links TRPM7 to the signaling pathways that mediate the mitogenic effects of growth factors and the proinflammatory effects of cytokines.

The PDGF receptor (PDGFR) is a receptor tyrosine kinase that mediates the mitogenic effects of PDGF by binding to and/or phosphorylating a variety of intracellular signaling proteins upon PDGF-induced receptor dimerization.

It mediates the mitogenic activation of mTOR signaling to the downstream effectors through regulation of a large number of protein kinases and phosphatases [49], [50].

SDF-1 mediates the mitogenic effects of E2 in breast cancer cells [ 50].

This pathway mediates the mitogenic and pro-inflammatory responses of insulin signaling while it does not affect glucose homeostasis [ 4].

We further investigated which IL-8 receptor(s) mediated the mitogenic function of IL-8 in lung cancer cells.