Sentence examples for mediating the mitogenic from inspiring English sources

The first one is mainly involved in mediating the mitogenic effect of insulin and IGFs, while the PI3K pathway, via Akt, mediates both metabolic and cell growth responses.

In MCF-7 cells, melatonin interferes with the estrogen response pathway through the suppression of ERα expression and transactivation to affect the level of growth regulatory genes mediating the mitogenic action of estradiol [ 33, 34].

This receptor may mediate the mitogenic activity of alpha 2M in vSMC culture.

The PDGF receptor (PDGFR) is a receptor tyrosine kinase that mediates the mitogenic effects of PDGF by binding to and/or phosphorylating a variety of intracellular signaling proteins upon PDGF-induced receptor dimerization.

It mediates the mitogenic activation of mTOR signaling to the downstream effectors through regulation of a large number of protein kinases and phosphatases [49], [50].

SDF-1 mediates the mitogenic effects of E2 in breast cancer cells [ 50].

This pathway mediates the mitogenic and pro-inflammatory responses of insulin signaling while it does not affect glucose homeostasis [ 4].

Activated ERKs, which are a type of MAP kinase, mediate the mitogenic and pro-inflammatory responses of insulin signaling.

We further investigated which IL-8 receptor(s) mediated the mitogenic function of IL-8 in lung cancer cells.

The latter is induced by IL-6 and mediates the mitogenic effects of this cytokine for hepatocytes (Ren et al, 2003).

It mediates the mitogenic response to the EGF family of ligands which includes both EGF and transforming growth factor-α (TGFα) (Carpenter, 1987).