Sentence examples for mechanistic data showing from inspiring English sources

The key findings in this study are the identification of an antimicrobial activity of PrP together with the characterization of epitopes mediating this effect, as well as mechanistic data showing that the antimicrobial activity is mediated by bacterial membrane permeabilisation.

This is supported by our mechanistic data showing that treatment with the full (active) cholera toxin protein increases immunostaining for the Tie2 receptor and induces the nuclear localization of the transcription factor Hes3, two processes characteristic of self renewing NSCs [22], [23], [24], [25].

This interpretation accords with mechanistic data, showing that the two montane specialists suffer pronounced metabolic depression in low-elevation populations living near their tolerance limits (Bernardo & Spotila 2006).

Dynamic studies contribute complementary and mechanistic data showing that defective vasoconstrictor and vasodilator responses to stimuli are often the first detectable changes in the retinal vessels of diabetic patients without retinopathy.

The classification of TCDD as a group 1 carcinogen is based in large part on mechanistic data showing tumor promotion through modification of cell replication and apoptosis mediated through the aryl hydrocarbon (Ah) receptor and related signaling pathways and responses, which are conserved across species [ 6, 7].

Our mechanistic data show how the limitations of each approach can be complemented by the other: macrophage activation induces enhanced trafficking and reduced inactivation of the antigen-specific antitumour T cells induced by the vaccine.

Finally, the empirical apparent first order model data were calibrated against the mechanistic Smoluchowski-Stokes model simulation data, showing excellent fits for a range of NC initial concentrations.

Therefore, if similar effects on endogenous DNA repair foci are detected in stem cells, this might provide a direct mechanistic link to the epidemiologic data showing association of MW exposure with increased cancer risk.

Both interpretations of the data either disruption of the balance between cellular repair systems and DNA damage or stress response are not mutually exclusive, and both may provide a mechanistic link to the epidemiologic data showing association of prolonged MW exposure with brain cancer risk (Hardell et al. 2008).

In making this evaluation, the Working Group took into consideration all the relevant data, including the substantial epidemiological data showing a positive association between consumption of red meat and colorectal cancer and the strong mechanistic evidence.

From a mechanistic perspective, our data show that the phenotype is largely rescued by anti-miR-33 oligonucleotides.