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Mechanistic data indicate that CYLD is essential for necrosis and serve as a target for proteolysis by caspase-8.
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A recent review of mechanistic data indicates that dichloromethane may act directly at specific sites in the brain such as ligand and voltage-gated ion channels; these pharmacodynamic modulations are similar to other chlorinated solvents including trichloroethylene and tetrachloroethylene (Bale et al. 2011).
Thus, whilst we have not demonstrated a direct mechanistic link, these data indicate that the increased lymphatic vascular density in ACKR2-deficient mice is associated with a hypotensive phenotype.
Pending future mechanistic studies, this data indicate that prostaglandin-mediated suppressive effects, or other, as yet to be identified differential TFM-C/celecoxib-related effects on TNF-α production may extend to other cytokines as well, and provide an important clue as to the more potent beneficial effects of TFM-C compared to celecoxib in the arthritis models presented here.
Taken together, these data indicate that mechanistic steps affected by loop 3 include the first pseuodotranslocation events after 80S ribosome association.
These data indicate a considerable mechanistic variance across the two reactions.
Although not providing complete mechanistic insight at this point, our data indicate that the selective enhancing effect of EPO on hippocampus dependent memory is mediated via profound changes in neuroplasticity.
We believe our collective data indicate that there are three mechanistic pathways for substrate utilization in high- Mr TRs.
Emerging data indicate that protein misfolding may be of mechanistic importance in these diseases.
Additionally, these data indicate that the unique GPCR expression patterns found may help clarify important mechanistic differences between the groups.
Our data indicate that the value of the technology is in its potential to provide mechanistic insight into the mode of action of a genotoxic compound.
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