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Genetic enhancer screens have revealed roles of miRNAs and other gene repressive mechanisms in development or other cellular processes that were masked by genetic redundancy.
In view of the protective role of SP-A against inflammatory reactions and oxidative damage, the two underlying mechanisms in development of HAPE, we examined the association of constitutional susceptibility to HAPE with polymorphisms in SP-A1 and SP-A2.
Importantly, the establishment of an efficient mouse ES cell culture system will allow investigation of many physiological mechanisms in development and cell behaviour in vivo or in vitro.
miR-184 has been previously shown to be controlled by epigenetic mechanisms in development.
Selection may even act more strongly on variance-stabilizing mechanisms in development than on the mean value of traits [ 21].
The thickening of the intima media in the development of atherosclerosis shares the same pathophysiological mechanisms in development and progression.
Similar(54)
Thus, further study is required to determine the full implications of the APP-death-receptor mechanism in development, adult physiology, and disease.
Rat studies indicate that cytotoxicity-induced cell proliferation (NOAEL at 1 ppm) is a key mechanism in development of nasal cancer….
In future studies, it would be interesting to analyze whether cleavage and inactivation of the translational regulator hnRNP K by Caspase-3 is restricted to the hematopoietic lineage or represents a more general mechanism in development and differentiation.
To elucidate underlying mechanisms in-vivo, infarct development was followed by ultra-high field MRI at 17.6 Tesla.
This could facilitate understanding of the molecular mechanisms in fruit development and maturation.
Related(20)
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