We are currently using this mutation to understand the mechanism of decreasing intracellular H2O2 concentrations.
Analogous to the economic mechanism of decreasing marginal utility, e.g. quick service without waiting time in the doctor's office might be valued as less important, if in general services are quick and people don't have to wait long.
The reaction of sulfide with Hg2+ to produce insoluble cinnabar (HgS) has been described as a principal mechanism of decreasing mercury availability for methylation in aquatic systems (Gilmour et al. 1998; Orem et al. 2011).
Direct cell cell contact has also been described as a mechanism of decreasing IL-12 production, for instance by tumor-derived CD4+CD25+ T regulatory (Treg) lymphocytes via CTLA-4-mediated signaling [ 23] or by CD200 CD200R interactions [ 24].
Together, the data suggest that the mechanism of decreasing collagen degradation in this in vitro model system by glucosamine may be mediated by the inhibition of advanced lipoxidation reaction, preventing the oxidation and loss of collagen matrix from labeled chondrocyte matrix.
The search for a mechanism of decreasing rate of macroevolution and decreasing variability of species in macroevolutionary time-scale, i.e. the third part of frozen plasticity theory, was inspired by the existence of phenomena described by Stephen J. Gould, Mark Webster and John A. Davison.
