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Although this mechanism of mechanical stimulation has not yet been fully clarified, it suggests that chondrocytes cultured in vitro with a certain dynamic mechanical stimulation could promote the secretion of extracellular matrix such as the proteoglycan and collagen [ 27].

Mechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffolds.

Mechanical stimulation has been implicated as an important regulatory factor in tendon homeostasis.

Research using alternate cell sources, scaffolds, bioactive factors, and mechanical stimulation has shown promise, but more research must be done to determine optimal combinations of these factors.

Mechanical stimulation has been reported to activate chondrocytes and to promote their synthesis of the extracellular matrix.

In the present study, a mechanical stimulation has been applied on the facial skin for 24 sessions over 8 weeks.

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Changes in COL2A1 mRNA levels caused by interleukin-1 treatment or mechanical stimulation have previously been demonstrated, but these did not involve a posttranscriptional mechanism (13, 46).

To improve mimicry of musculoskeletal physiology, dynamic cultures, provided via shear or mechanical stimulation, have also been developed and demonstrated as beneficial.

These differences were amplified with time, so that after 7d, bone marrow cells subjected to mechanical stimulation had differentiated into osteoblasts (n = 8; Fig. 2C).

Moreover, the mechanical stimulation had little effect on membrane potential change since the indentation was displaced 100 µm away from the soma, in which the distal mechanical force could only alter less than 3 mV of membrane potential on a neurite-free neuron, even the neuron was surrounding with glia cells (Fig. 3 & Fig. 4).

Chondrocyte responses towards mechanical stimulation have been less studied.

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