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Our type 1 diabetes population is defined from laboratory measures of islet autoantibodies instead of physician classification.
In addition, we have measures of islet autoantibodies and C-peptide at the clinical onset of diabetes which are not typically available in cross-sectional studies of DR. One limitation of our study is that we only have a current HbA1c which may not adequately reflect blood glucose control over the course of the study.
Insulin and glucagon secretion as well as insulin content were used as measures of islet function.
Moreover, several type 2 diabetes CpG-SNPs are associated with measures of islet function.
Since insulin-positive cells have to detach and migrate away from the pancreatic ducts to form mature islets, one of the measures of islet cell migration is the degree to which insulin-positive cells remain in direct contact with the ductal epithelium.
Similar(55)
Glucose-stimulated insulin secretion (GSIS) is thus a well-accepted measure of islet function.
The dotted line indicates the cell number/IE that should be obtained independent of the size of the islet, if IE were an accurate measure of islet volume.
The kinase activity of CDK5-p35 immunoprecipitated with anti-p35 antibody (C19, Santa Cruz) from an equal protein amount of islet extract was measured using histone H1 as a substrate in the absence or presence of 20 µM roscovitine.
Furthermore, it has even been suggested that those with alcoholic pancreatitis may fare worse than others undergoing TP-IAT in measures of QOL, islet yield, and insulin dependence.
Since similar TH activity values were recorded in islets isolated from S and SD rats, the enzyme activity measured was of islet rather than neural origin.
Further, we have measured TH activity in the endocrine pancreas of normal adult rats, recording comparable TH activity values in islets isolated from either control or solarectomized rats (330 ± 40 vs 300 ± 80 pmol/mg protein/h), indicating that the TH activity measured was of islet rather than neural origin [ 15].
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