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Average congestion window size (cwnd): the size in bytes of the congestion window at the TCP sender, averaged over all prediction trials, defined as: 1 T ∑ t = 1 T cwnd t, where c w n d t is the congestion window size measured at trial t.

Serum creatinine and cystatin C were measured at trial end and 6 8 weeks after discontinuation of trial therapy.

Also, cross level bias cannot be ruled out in our metaregression analyses of treatment effect moderators (which are measured at trial level); hence care must be taken in extending the treatment modifying effects to the individual level, particularly for age.

Previous analyses by our group of human sural nerve biopsies harvested as part of a double-blind, placebo-controlled, 52-week trial of ALC for DN (6, 7) revealed that elevated serum triglycerides measured at trial onset correlate with DN progression (7) and that the alterations in immune response and lipid metabolism genes are also associated with progressive DN (8).

Our initial demographic analyses of these participants revealed that elevated serum triglycerides measured at trial onset correlated with DN progression after correcting for baseline DN severity and clinical factors, such as sex, age, duration and types of diabetes, insulin treatment, ALC treatment, and HbA1c (7).

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On the other hand, clinical trial outcomes are measured at the trial participant level.

Spontaneous firing rates were measured during two seconds before stimulus onset and averaged over all trials measured at a given condition (usually ≥10 trials).

Weight and height were measured at enrolment into the trial and at the two subsequent antenatal care checks, by trained maternal and child health (MCH) staff of local hospitals.

An exception was follicular phase total and non-SHBG estradiol measured at the last DISC trial visit when women in the highest quartiles of these hormones had significantly lower %DBV compared to women in the lowest quartiles.

Another two groups of cockroaches were subjected to five sets of P−/V+ forward-pairing trials, and salivation responses to these odors were measured at 30 min after conditioning trials in one group and at 1 day after conditioning trials in another group (Fig. 3D F).

Body weight was measured at the start of the trial (15 weeks of age) and at the end of the trial (19 weeks of age) and feed intake was recorded.

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