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The application of monoclonal antibodies (mAbs) provides a rapid means of pathogen identification; antibodies to immunoglobulins from different fish species can be used to monitor the host response following vaccination; and mAbs also have the potential for screening broodstock for previous exposure to pathogens.
The sensor technology presented here represents a rapid and facile means of pathogen detection in low-resource settings, as indicated by the detection of gDNA in blood.
While serological responses to haptens were first demonstrated to illustrate the capability of the immune system to recognize diverse antigens, it appears that adaptive immune recognition of hapten-like pathogen-derived organic compounds and chemical modifications of host molecules can serve as a means of pathogen surveillance and monitoring of injury or altered physiological states.
Antibodies specific for pathogen-produced small compounds and chemical modifications of host molecules have also served as a means of pathogen surveillance (Daneshvar et al., 1989; Temmerman et al., 2004) and to monitor injury or altered physiological states (Vossenaar et al., 2004; Kim et al., 2006; Yang and Sauve, 2006).
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The fact that surface-bound PLG retains its proteolytic activity, even in the presence of serum inhibitors, suggests this process as a suitable means of pathogens to readily disseminate and to persist in the host.
Micro-organisms are recognised by the host by means of pattern recognition receptors such as the TLR, which distinguish friend from foe by means of pathogen-associated molecular patterns on the bacterial surface.
Therefore, while the "hot" organism may change and while food safety practices are improving, there remains a growing need for enhanced means of food pathogen detection.
The mean duration of pathogen excretion was significantly shorter in patients given antibiotics (MD -2.74 days, 95% CI -3.07 to -2.40, 11 trials, 1009 participants, Analysis 1.6).
It also appears likely that since the macrophages are body's innate means of countering pathogens, they might have evolved to recognize as many features of pathogens as possible.
This according to Barro et al. (2006), Mensah et al. (2002) and Bryan et al. (1997) are possible means of transmitting pathogens into foods.
DNA-based real-time quantitative polymerase chain reaction (qPCR) is a fast, sensitive, and highly specific means of enumerating pathogens.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com