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Mechanisms of pathogen clearance by platelets may be direct, through the release of various antimicrobial peptides and indirect via the release of platelet-derived mediators that coordinate chemotaxis and activation of immune cells [83, 116 118, 120, 121].
Here, we briefly recount the generally recognized mechanisms of pathogen protection by AM fungi and present evidence, where appropriate, for functional diversity among AM fungal taxa with regard to these mechanisms.
As the HFD and rosiglitazone differentially polarize the macrophage and that the responses against Candida albicans are different, we wondered whether the macrophage mechanisms of pathogen elimination (phagocytosis and reactive oxygen species production) were also modified.
Many genetic tools are available to address the mechanisms of pathogen action in Drosophila.
The transcriptional status of in vivo derived bacteria may correlate with mechanisms of pathogen survival and proliferation within host cells.
As SOT patients are already on immunosuppressive regimens (97), reducing mechanisms of pathogen clearance may not be ideal.
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Once the pathogenic mechanisms of pathogens and the corresponding defensive mechanisms employed by hosts are uncovered, novel strategies that assist hosts in responding to microbial infection may be developed.
Sequencing of bacterial genomes is an essential approach to understand the virulent mechanisms of pathogens and the evolutionary relationship among close related pathogenic strains.
Human vaccine development remains challenging because of the highly sophisticated evasion mechanisms of pathogens for which vaccines are not yet available.
Nevertheless, differential proteomic analyses of bacterial strains cultured under distinct growth conditions open a new window for us to study the mechanisms of pathogens' adaptations to specific environment on a systems-level.
Given the highly conserved links between innate immunity and osmoregulation in mammals, understanding the molecular mechanisms of osmosensing and osmosensitive gene expression in C. elegans may also shed new light on mechanisms of pathogen-induced cellular toxicity.
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