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Exact(5)
Even in mice receiving the highest dose of rFst (100 μg daily), the mean prostate weight was not significantly different from that in vehicle-treated mice, while the levator ani weight was 25% higher than in vehicle-treated controls.
Table 2 of Tyl (2009) also includes data from a publication by Morrissey et al. (1988) showing a mean prostate weight of 58 mg in 23-week-old CD-1 mice.
However, this study involved comparing data from two laboratories, and Tyl omitted from her table the data from the second laboratory that reported a mean prostate weight of 35 mg in 23-week-old CD-1 males.
Morrissey et al. (1988) observed that the laboratory reporting the mean of 58 mg also had a higher standard deviation and lower statistical sensitivity than the laboratory reporting the 35 mg mean prostate weight.
The mean prostate weight reported by Heindel et al. (1995) for 16- to 17-week-old CD-1 male mice was 48 mg, which is similar to most other findings, but contrasts sharply with Tyl's mean prostate weights of 74 mg for the F1 males in her BPA study (these males were identified in Table 1 of Tyl's commentary as being examined at 18 weeks of age).
Similar(55)
At baseline (without testosterone), the mean ventral prostate weight of the male Wistar rats was 45 mg/100 g body weight.
When an oral dose of 50 mg E. ulmoides extract was co-administered together with 5000 μg of IM testosterone (n = 5 for each combination treatment), the mean ventral prostate weight increased to 93 mg/100 g body weight, demonstrating a highly significant δ difference over baseline of 53 mg/100 g body weight (p-value < 0.001).
Prostate weight, prostatic index, and the testosterone and dihydrotestosterone (DHT) levels in serum and prostate, and the serum prostate specific antigen (PSA) levels were measured; prostate tissues were taken for histopathological examination; and serum biochemical analysis was also performed.
The BPH rats displayed an increase in prostate weight, prostatic index with increased testosterone and DHT levels in both the serum and prostate, and increased serum PSA levels.
On the basis of prostate weight, the mean, median, SD, and variance was 56.48 cm, 49 cm, 27.34, and 747.94, respectively.
Mean control mouse prostate weights by lobe and age in our studies are presented in Table 1.
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