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Net changes in mean plasma folate concentrations are shown in Figure 3.
Baseline (8 am sample) mean plasma folate concentrations did not differ within or between subjects.
In the current study, mean plasma folate from the entire cohort was above the reference normal range [ 41].
On average, participants in the FACIT trial were younger (60 compared with 66 y) and had lower mean plasma folate concentrations (12 compared with 15 nmol/L) than those in all of the global cognition trials.
Although there was no significant difference in mean plasma folate concentrations between cases and controls, using published reference values for plasma folate (Christenson et al. 1985), 69.5% of cases versus 58.4% of controls had low plasma folate (< 9 nmol/L; p = 0.009).
The mean plasma folate level was higher in the present study than in our first study of As exposure and global DNA methylation (Pilsner et al. 2007) (12.6 vs. 8.6 nmol/L, respectively), and a smaller proportion was folate deficient (31.3% vs. 64.6%).
Similar(53)
The mean cord plasma folate and B12 values (52.7 nmol/L and 370.4 pmol/L, respectively) were more than twice those in maternal blood (p < 0.0001), whereas cord plasma homocysteine was 11% lower than maternal plasma homocysteine (p < 0.0001) (Table 2).
However, in 36 Alzheimer's patients, Serot reported a 17% mean decrease in CSF folate and an 8% mean decrease in plasma folate compared with the 36 elderly controls [ 38].
Analysis of covariance (ANCOVA) was used to evaluate differences in mean plasma t-hcy, folate, and vitamin B12 levels among groups, including age at sampling and gender as covariates.
In the active treatment group, geometric mean (95% CI) of plasma folate increased by nearly 270% and plasma vitamin B12 doubled.
Mean plasma serum levels in rats fed with folate deficient chow for 14 days decreased from 110 ± 21 to 11.0 ± 4.3 nM (that is, comparable with human physiological levels).
Related(20)
mean serum folate
median plasma folate
mean plasma elimination
mean plasma membrane
mean plasma clearance
mean plasma hemopexin
mean plasma total
mean plasma ivermectin
mean plasma ketamine
mean plasma triglyceride
mean plasma cotinine
mean plasma efavirenz
mean plasma level
mean plasma ghrelin
mean plasma fetuin-A
mean plasma vit
mean plasma glucose
mean plasma concentration
mean plasma half-life
mean dietary folate
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