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Exact(6)
(G ) Increase in calculated mean fibril length in GM6001-treated tendon-like constructs.
Estimation of collagen mean fibril lengths in the constructs showed that inhibition of MMPs resulted in increased mean fibril length, as was observed in embryonic Mmp14 KO tendon.
(B ) Estimated mean fibril length 645 ± 14 µm WT and 674 ± 24 µm Mmp14 KO shows that the absence of MMP14 does not affect fibril length at birth.
The effective diffusion coefficient of αB-crystallin in the presence of αSyn fibrils corresponds, when modeled as rotating rigid rods (31), to a mean fibril length of 260 ± 140 nm.
(B ) Quantification of mean fibril length based on the number of tips identified shows that E15.5 WT fibrils are shorter than fibrils in age- and anatomical position-matched tail tendons from KO mice (308 and 266 fibrils tracked, respectively).
Therefore, given the same transverse area occupied by collagen fibrils in WT and KO tissue, the difference in collagen mean fibril length equates to a ∼2.5-fold reduction in fibril number in KO tendon.
Similar(54)
HEWL fibrils, obtained at pH 1.6 and at 65 °C, exhibited a height of about 3 nm and a fibril length on average of about 3 μm.
The elastic modulus for each fibril is determined from the average value of the DMT modulus obtained along the fibril length.
With a comparable fibril length (model 5.9 8 μm, measured 7.5 μm) and appropriate fibril anisotropy the anisotropic model provides a better representation of the collagen fibril microstructure.
Results showed that the fibril length decreased with the stretch ratio until 2.0% and then increased.
The model describes successfully the kinetics and the complete fibril length distribution in both conditions.
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