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The mean dose increase by Berger et al. over 12 months was 36%.
The mean dose increase was 28% (Table 2 and Table 3 >).
In our study, patients who developed NMS, a progressive mean dose increase 15 days prior to the confirmed diagnosis of NMS was observed.
In this large observational study, PD patients were able to maintain mean hemoglobin concentrations >11.0 g/dL after conversion to extended dosing of darbepoetin alfa Q2W, with no mean dose increase.
A progressive mean dose increase 15 days prior to the confirmed episode of NMS was observed (241.7 mg/day during days 1 15 to 346.9 mg/day during days 16 30) and the mean ratio of dose escalation for NMS patients was 1.4.
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Wolpert et al. revealed a mean insulin dose increase of 42 % was needed for a high-fat meal (60 g fat) compared to the low-fat meal (10 g fat), however, given patients still experienced significantly hyperglycaemia following the high-fat meal, this dose is likely to be an underestimation [ 19].
A subsequent study by this group used predictive modelling to optimise the insulin dose in patients using insulin pump therapy for the addition of 35 g of fat and 32 g of protein to a meal, finding a mean insulin dose increase of 78 %, using a combination-wave with 30/70 % split over 2.4 h [ 69].
Between 1991 and 2005, the mean ESA dose increased about four-fold in dialysis patients [ 4].
By study end, no patients were receiving sulfonylurea therapy in the linagliptin group, but mean daily dose increased 5.0% in the placebo group.
It has been demonstrated in cattle orally challenged with BSE that the incubation period followed a lognormal distribution, with decreasing mean as dose increased [ 13], and thus a similar effect of dose on onset of the first clinical signs and possibly the disease duration is expected.
The mean average absorbed dose increased by 11.2 ± 6.9 Gy.
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