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Mean dose intensity was ⩾90% for each drug throughout the study.
Patient compliance according to mean dose intensity was 90 ± 15% and 88 ± 14%, respectively.
Mean individual dose was 15.1±1.4 mg m−2 during initial six cycles, mean dose intensity 94±9%.
Although patients who reached different epirubicin levels showed differences in mean dose intensity, such differences were not statistically significant.
The mean dose intensity for S-1 was 251.4 mg m−2 per week (89.8% of the planned dose) in the gemcitabine and S-1 arm.
The mean dose intensity of 97 mg m−2 week−1 is higher than reached with the standard 3 weekly i.v. schedule.
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During CCRT, the mean dose intensities relative to the target dose of cisplatin was 69.6%.
The mean dose intensities relative to the target dose of docetaxel, cisplatin, and TS-1 were 97.7%, 98.6%, and 97.7%, respectively.
The mean dose intensities of irinotecan and capecitabine were 61.5 mg m−2 week−1 and 11 343 mg m−2 week−1, respectively, which were 94.7 and 92.6% of their respective intended doses.
The relative mean dose intensities of chemotherapy were comparable in both the PC and PE groups (carboplatin [90%] and paclitaxel [89%] vs. cisplatin [84%] and etoposide [86%]).
Mean irinotecan dose intensity (DI) of 45.4 mg m−2 wask−1 was 85.2% of the planned DI; mean docetaxel DI of 17.5 mg m−2 wask−1 was 80.6% of the planned DI.
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