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Mean diffusivity was increased in chess players compared with that of controls in the left superior longitudinal fasciculus and the Elo score (a chess tournament ranking) was inversely related to mean diffusivity within the right superior longitudinal fasciculus.

Following traumatic brain injury, the extent of damage to the hippocampi is known to predict memory impairment (Tate and Bigler, 2000), and mean diffusivity within the hippocampal formation has been shown to predict associative memory function (Salmond et al., 2006).

In conclusion, this work shows for the first time a widespread reduced mean diffusivity within the white matter of subjects with sporadic CJD.

We show for the first time significant global reduced mean diffusivity within the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary involvement of the white matter, rather than changes secondary to neuronal degeneration/loss.

Tract-based spatial statistics analysis showed significant reductions of mean diffusivity within the white matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere, with a strong trend (P = 0.06) towards reduced mean diffusivity in most of the white matter bilaterally.

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The between-group differences were most clear for fractional anisotropy and mean diffusivity, with less extensive but still marked differences seen for axial diffusivity and much more limited differences seen for radial diffusivity.

CBF = cerebral blood flow; f 0  = isotropic diffusion fraction [ 20]; MD = mean diffusivity.

Figure 6 represents the calculation of effective oxygen diffusivity of concrete which means diffusivity with effective pore due to moisture.

Its influence was primarily seen in axial diffusivity and mean diffusivity.

Diffusion parameters that were used to quantify microstructural white matter abnormalities (fractional anisotropy [FA], mean diffusivity [MD], radial diffusivity, and axial diffusivity) were obtained for each tract.

In order to include whole white matter summary measures of fractional anisotropy and mean diffusivity in the structural equation model (see below) we extracted the median fractional anisotropy and mean diffusivity for all non-zero white matter voxels included within the voxel-based analysis mask using the 'fslstats' function in FSL.

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