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It is a transition metal that exists in various oxidation states and may thereby act as a pro-oxidant.

In the desmosome, they bind to DSG1 and DSC1 and may thereby act as tumour suppressors by stabilising intercellular adhesion.

Epicardial adipose tissue may thereby act as a paracrine organ in the induction of inflammation and the regulation of the metabolism of vascular smooth muscle cells.

The CP must be able to offer many different kinds of help related to feelings of isolation, survival, and rehabilitation, and may thereby act as a sounding board for women's experiences and a shelter for emotional expressions.

This recovery of hormonal, structural, and biochemical parameters related to male reproductive physiology may be attributed to the increase in serum insulin levels in arecoline-treated diabetic rats, by reverting pancreatic β-cell degeneration, and may thereby act as a positive protective factor for men with type 1 diabetes.

Similar(55)

We therefore hypothesized that P-Rex could act as an intermediary for the PI3K-dependent activation of Rac – two enzymes which have been implicated in late phase LTP in the hippocampus – and may thereby play a role in cerebellar LTP.

These findings raise the possibility that syt 7 may be targeted to, and thereby act at the plasma membrane, as proposed by Sugita et al. (2001), to drive replenishment by either conveying SVs from reserve pools to the RRP (Kuromi and Kidokoro, 1998; Murthy and Stevens, 1999; Ikeda and Bekkers, 2009), or clearing vesicle release sites (Kawasaki et al., 2000; Wu et al., 2009; Neher, 2010).

By enabling, catalyzing and safeguarding single electron transfer reactions these mitochondrial antioxidants may enhance energy and oxygen metabolism efficacy and thereby act as very potent adaptogenic agents with profound neuroprotective activity [ 40, 76, 217].

Also, neutering may help to decrease a high level of hyperactivity/aggression/stress and thereby act as a protector against potential seizure provocation.

Thus, future informatics tools that incorporate cognitive strategies into the system design may include the heuristics (System 1) of expert clinicians and thereby act as a cognitive extension to notify (System 2) clinicians about travel history when appropriate.

Also, it has been shown to specifically inhibit DYRK1A, an enzyme responsible for phosphorylation of tau and thereby may act to slow tau pathology in AD and DS [ 58, 59].

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