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The study investigates whether an antibiotic applied to the eye would affect bacteria in the nose and mouth as well, which might indicate that what seems to be an innocuous and limited treatment may profoundly change a wider area of the body and foster resistant microbes.

The biochemical composition of the tumour microenvironment is poorly known, but it is understood that it may profoundly change depending on tumor type and the host immunocompetence [15].

The activity of a single TF may profoundly change the tumor cell phenotype, as for example, RNAi-mediated knockdown of Klf17 (Krüppel-like factor) promotes EMT and lung metastasis of 168FARN cell line, whereas overexpression of Klf17 in the metastatic 4T1 cell line considerably limits their metastatic potential [73].

Different chemical modifications, which can be introduced to obtain stabilized analogues, may profoundly change peptide affinity or specificity.

Climate change may facilitate habitat extension for sandfly and other phlebotome vectors northwards, whilst the ecology and geography of the tick species responsible for transmitting Lyme disease may profoundly change.

Modification by aldehydophospholipids may profoundly change the molecular properties of polypeptides, including net charge, conformation, state of association, enzymatic and signaling functions and last but not least, biological recognition, e.g. by receptors and the immune system (see Sections 2 and 3) (Fig. 3).

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Changes in the damping coefficient of the arterial pressure transducing system may profoundly alter cardiac output measurements.

And political strategists say that the outcome of elections next March may be profoundly changed by the events of Sept. 11.

Since most of the landscapes worldwide are covered by road networks and various human objects, the marking behaviour of wild mammals may be profoundly changed due to human-caused habitat modifications.

Subsequently presented external cues can also over-ride internal cues to agency such that the memory for agency may be profoundly changed.

While incentivising clinicians may well result in better data quality it should not be assumed that the quality of care (in its most holistic sense) improves, although the care of the patient may be profoundly changed.

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