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The tissue formed in vitro may not accumulate enough extracellular matrix, and the resulting mechanical properties are only a fraction of the native tissue.
Next to individualized treatment prediction which may not accumulate the same quantities of data, the next steps may further largely benefit from trans-diagnostic databases.
It is also possible that the biglycan degradation product may not be stably retained within the cartilage matrix and hence may not accumulate in large amounts.
Now chemical engineer David Holbrook and colleagues at the U.S. National Institute of Standards and Technology report that certain nanomaterials may not accumulate in organisms at higher trophic levels.
Oxidative base damage such as 7,8-dihydro-8-oxoguanine (8-oxoG) is repaired by the base excision repair (BER) pathway and may not accumulate in Ercc1 Δ /− mice.
Depending on the study population and sample size, use of the second hybrid option may not accumulate enough events for full evaluation, especially for ruling out an RR of >1.3.
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This study shows that for neglected children, additional abuse may not additively accumulate risk when considering intelligence outcomes.
According to previous studies, oxygen may not necessarily accumulate within the near enamel surface [20, 21], whereas dentin may act as a true reservoir of oxygen molecules [22].
This indicates that these mutants are able to be transported but may not stably accumulate at the poles.
This is partly because their numbers may not otherwise accumulate enough to be distinguished from random events, but also because such testing associates the gene with the phenotype.
The use of protocells that interact with, but do not accumulate, viruses may provide significant advantages over current antiviral drugs, and this general approach may have wide potential for antiviral development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com