Sentence examples for may lack efficacy from inspiring English sources

For treatment of small tumour clusters and metastases, β-emitters may lack efficacy due to the relatively large tissue penetration and low linear energy transfer (LET).

Thus, monoclonal antibodies targeting tumor-associated antigens may deliver the required specificity but may lack efficacy.

γ-Secretase inhibitors may lack efficacy in preventing APP cleavage by enzymes resultant from mutated PSEN genes [ 6, 7].

Although influenza vaccines may lack efficacy for a variety of reasons (Osterholm et al., 2012), antigenic drift causes efficacy of a fixed vaccine formulation against circulating viruses to decline over time.

Because both alternatives are acceptable and currently widely used in practice, providing postmenopausal women with information about their CYP2D6 genotype will allow them to make an informed choice about their adjuvant hormonal treatment and, most importantly, avoid the potential of taking a therapy that may lack efficacy when there are acceptable alternatives.

27 118 121 124 Importantly, melatonin is protective in lipopolysaccharide-sensitised HI. 125 Given the evidence outlined above indicating therapeutic cooling may lack efficacy following infection-sensitised HI, 44 45 melatonin may prove an effective immune-modulating neuroprotectant in such cases.

Even blocking reagents such as soluble FcγRs may lack sufficient therapeutic efficacy because they will prevent IgG-containing immune complexes from binding to activating but also inhibitory FcγRs.

To transport current best practice from the oncology clinics of high-income countries and use them in less developed healthcare systems may not only lack efficacy but could ultimately cost lives.

Similarly, when the polarization of the compensation level becomes more serious, employees may lack their self-efficacy and job satisfaction, and thus lose self-respect and intrinsic motivation (Heneman 1992; Deci et al. 1999).

The ineffective treatments reported in this study may have lacked efficacy for a number of reasons relating to fish appetite and feeding rate, sub-therapeutic dosing due to underestimated biomass or variation in medicine inclusion level in the feed, amongst others.

Because general practitioners may lack evidence showing a similar efficacy of acetaminophen and non-steroidal anti-inflammatory drugs, we present the design of a randomized open-label trial to investigate the efficacy of a non-steroidal anti-inflammatory drug (diclofenac) compared with acetaminophen in new consulters with knee osteoarthritis in general practice.