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Conventional anti-infective agents may kill bacteria but at the same time release bacteria-derived agents, such as lipopolysaccharide (LPS) or lipoprotein (LP), hence causing the devastating consequences of the pro-inflammatory cascades in severe sepsis and septic shock.
Antimicrobial peptides (AMP) may kill bacteria without releasing pro-inflammatory factors.
Antimicrobial peptides (AMP) may kill bacteria without releasing pro-inflammatory factors, but their application may be impeded by high toxicity, hemolysis, nephrotoxicity and neurotoxicity [ 1].
Compared to conventional anti-infective agents, some AMP may kill bacteria but also simultaneously neutralize released pathogenic factors, like lipopolysaccharide (LPS) or lipoprotein (LP), thus preventing the devastating consequences of the pro-inflammatory cascades in severe sepsis and septic shock.
In earlier studies, cathelicidins (LL-37 and CRAMP) were expressed at select epithelial interfaces and may kill bacteria such as group A Streptococcus., Studies in mice showed that deletion of the cathelicidin gene, Cnlp, results in increased susceptibility to group A Streptococcus infection.
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NDGP may also kill bacteria entering through the lateral canals following contact with ND antibiotic agents.
The natural genetic mutations that constantly occur in all organisms mean that although a new antibiotic may initially successfully kill bacteria, it may not remain effective for long.
Although cooking may kill the bacteria, handling the raw dough could spread the contaminant to hands and cooking surfaces.
This balance may be thrown off by antibiotics, which may be necessary to destroy an infection but may kill friendly bacteria in the process.
These therapies may kill skin bacteria non-specifically, impacting the homeostasis of resident dermal microflora [3], [4].
Wastewater is commonly disinfected via ultraviolet radiation or chlorination, which may kill resistant bacteria, but ARGs are more recalcitrant (Auerbach et al. 2007; Kim et al. 2010; McKinney and Pruden 2012; Munir et al. 2011).
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