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This finding suggests that the high capability for DENV infection in human monocytes in vivo may increase viral yield, which may create more problems in the efficient clearance of the virus and thus increase the likelihood of a severe clinical outcome of dengue in G6PD-deficient patients.

In vitro experiments have shown multi-mutations may increase viral replication efficiency in Lamivudine resistant strains [ 21].

We initially hypothesized that this finding could reflect increased viral load among hormonal contraceptive users given that previous studies suggested that HPV contains hormonal responsive elements and that hormonal exposure may increase viral replication[ 18].

In addition, non-adherence to ART may increase viral resistance to antiretroviral drugs and transmission of drug-resistant strains of HIV (Bangsberg et al., 2006; Sethi, Celentano, Gange, Moore, & Gallant, 2003; Wainberg & Friedland, 1998).

Although malaria may increase viral replication in the short term, the concern that the malaria-associated increase in viral replication may accelerate HIV disease progression has not been proven (13 ).

This possibility arises because a high density of Wolbachia in hosts may increase viral blockage but decrease host fitness (Chrostek et al. 2013; Sinkins 2013; Martinez et al. 2014), and such a trade-off could have driven past cycles of Wolbachia strain replacements in natural populations.

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These include an influenza-induced increase in S. aureus specific adhesion throughout the respiratory tract and S. aureus specific proteases, which may increase influenza viral replication (18 – 20 ).

As a result, a prolonged viremia may increase the viral load in the CNS and is more likely to lead to more severe CNS disease and further cardiopulmonary failure [ 25].

New sexually transmitted infections may exacerbate discomfort, and can increase viral load and accelerate disease progression [5], [6].

The use of chimeric receptors suggests a more flexible usage of CCR5, which in turn may indicate increased viral resistance to inhibition by CC-chemokines.

Prior work from our group and others suggests that directly administered antiretroviral therapy (DAART) delivered in opioid treatment programs (OTPs) may increase rates of viral suppression.

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