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These changes in primary metabolism may further regulate many structural and transcriptional regulators.
SRC may further regulate p120 by modulation of the stoichiometry of p120 phosphorylation at specific sites.
Another identified candidate gene may further regulate the excitability of GABA neurons and GABA release.
RARA (see row 7 of Table 1, with betweenness 24 and permutation FDR 0.005) encodes a specific receptor for retinoic acid, which may further regulate germ cell development during spermatogenesis and the expression of specific genes through recruiting the chromatin complex (KMT2E, MLL5, etc).
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However, these studies examine full proteins where it has been suggested that the presence of neighboring amino acids and protein confirmation may help to further regulate how a protein interacts with different GAGs.
The storage lipid accumulation may be further regulated by new transcription factors, kinases/phosphatases and/or proteins involved in RNA regulation [ 27- 31].
Release of sGAG from IL-1-stimulated fibrocartilage may be further regulated by MMP-mediated collagen degradation.
Compartmentalization implicates the importance of the 5-LOX nuclear localization sequences, which may be further regulated by phosphorylation.
In addition to the NoLS, a phosphorylation-mimicking mutation of a specific serine residue (S299D) strongly stimulates nucleolar retention, indicating that nucleolar retention of extended-C/EBPα may be further regulated through phosphorylation.
Even at basal metabolic conditions, adiponectin did exhibit some alteration in junctional molecule mRNA expression and some potential changes in nitric oxide production or adiponectin receptor expression, suggesting that these factors that regulate endothelial physiology may be further regulated in metabolic dysfunction.
Repression of MYC and the early growth-response gene EGR1 in this group may further negatively regulate E2F1 and its target gene expression.
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