Some progress has been made in computationally predicting amino acid changes that make a protein temperature-sensitive in function (Chakshusmathi et al. 2004; Poultney et al. 2011; Lockwood et al. 2011), and the identification of causal TS-EL mutations from chemical mutagenesis screens may help further guide such efforts.
Apart from insights in important molecular properties for CYP inhibition, the present results may also guide further design of curcumin analogues with less susceptibility to drug drug interactions.
In addition, more sophisticated statistical analyses such as the use of the odds ratio matrix may help guide further research into interaction effects between predictor variables and how these might affect the psychometric properties of risk assessment tools such as the Braden Scale.
Although our estimate of sensitivity is only applicable to the interpretation of the RVDSS data over the study period, similar estimates for specific cohorts or laboratory procedures may help guide further investigation into the reasons for the large number of false negative test results.
Genotypic data from our study may efficiently guide further application of this diversity in the long-term management and reforestation of this tree species across western North America.
Genotypic and phenotypic information compared in this study may efficiently guide further exploration of this diversity for facilitating its practical use.
The emergence of language and complex social cognition may have prompted natural selection to further guide the development of our brains and nervous systems.
The timing of biopsies may have also influenced the ability to detect changes following ACE inhibition and, therefore, early biopsies, where feasible, may guide further mechanistic work in this area.
Whether an additional reduction guide based on K-wires may further improve accuracy in case of soft-tissue tension has to be evaluated in future studies.
