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However, it is still possible that Thr668 and its phosphorylation may functionally regulate synapses in the Central nervous system, especially those involved in memory formation in the hippocampus.
Strong correlations were observed, suggesting that these 2 lncRNAs may functionally regulate LV remodeling.
To investigate whether miR-34a may functionally regulate Notch1, we assessed Notch1 mRNA and protein expression in miR-34a mimic-transfected cells.
Altogether, given the role of Nrf2 in antioxidant defense mechanisms coupled with the potential modulation of cellular oxidative status by Carmustine treatment, we hypothesized that Nrf2 may functionally regulate tumor cell sensitivity to the cytotoxic effects of Carmustine, a widely used intracerebral chemotherapeutic agent.
Similar(56)
VDAC1 interacts directly with, and may be functionally regulated by the anti-apoptotic BCL-2 family protein BCL-XL [ 1, 29- 32] or the proapoptotic BH3-only proteins BAD [ 33] and BID [ 34].
Sequence comparisons between ER and RAR may reveal important differences between these receptors that functionally regulate their interactions with coactivators and BRCA1.
While more detailed investigations are necessary to verify such a model, an essential function of Merlin and the ERM proteins may be to work in concert to physically and functionally regulate the cellular interfaces of metazoa.
The second is by means of similarity between ligand sets that functionally regulate their targets [7].
Phosphorylation has been demonstrated to functionally regulate most of Bcl2 family members.
However, NMD has been shown to functionally regulate splicing factors (Barberan-Soler et al. 2009; Weischenfeldt et al. 2012), so relative changes in isoform expression may not only be due to direct targeting.
Importantly, we observed that genes other than MAPT are functionally regulated by the inversion haplotypes as well and may therefore be of importance in diseases associated with the inversion region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com