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We hypothesize that such dynamic functional networks are organized around a set of rules that constrain their spatial architecture – which brain regions may functionally interact – and their temporal architecture – how these interactions fluctuate over time.
Our findings that Dyrk1A/Mnb interacts and enhances Synj function further raises the interesting possibility that co-upregulation of both Dyrk1A/Mnb and Synj may functionally interact and perhaps contribute to some of the Down syndrome phenotypes.
These results suggest that: (1) both muscarinic and nicotinic receptors may functionally interact to synergistically modulate n-back working memory, and (2) that n-back working memory impairments in schizophrenia may in part be due to reductions in both muscarinic and nicotinic receptors.
In transfected F9 cells, activation of a TH-driven reporter requires both rITF2 and CDP2, suggesting that the proteins may functionally interact.
Thus, we cannot rule out the possibility that RIP may functionally interact with caspase-10 to mediate the activation of an alternative cell death.
As HIV-1 and HSV-2 may functionally interact in the genital mucosa [28],we wondered whether HMGB1 released by HSV2-infected cells might modulate HIV-1 reactivation as well.
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In human mammary carcinoma, AP-2γ may also functionally interact with these genes to influence tumor progression besides transcriptionally activating their expressions.
We next examined whether TRAF5 may physically and functionally interact with MAVS.
The same holds true for cross-linking experiments, in which proteins resident in the same micro-environment may become linked together even if they do not functionally interact with each others.
This may be the case since APE1 and NEIL1 have been shown to functionally interact and to stimulate the activity of hOGG1 [ 29- 32].
Here we show that the different cytosolic Hsp70 systems functionally interact with Hsp110 to form a chaperone network that interacts with newly translated polypeptides during their biogenesis.
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may functionally diverge
may functionally reorganize
may functionally explain
may functionally distinguish
may functionally sequester
may functionally correspond
may functionally be
may functionally disrupt
may functionally intersect
may functionally associate
may functionally contribute
may functionally differ
may functionally segregate
may functionally replace
may functionally synergize
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