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Therefore, combining low doses of chemotherapeutic agents at close regular intervals may enhance efficacy while reducing the toxicity.
There is recent evidence that HIF-1 is upregulated in response to doxorubicin and HIF-1-targeting strategies may enhance efficacy of doxorubicin, which is frequently used to treat many cancers including HCC [ 83].
In the endocrine treatment of HR-positive HER2-positive tumors, in which overexpression of HER2 may confer resistance to endocrine therapy, concurrent inhibition of HR and ErbB2 may enhance efficacy.
Bevacizumab, a humanised monoclonal antibody directed against all active isoforms of VEGF, does not appear to be effective as a single agent in breast cancer but may enhance efficacy when combined with other treatments.
Many in the field of immunotherapy today feel that combination therapies may enhance efficacy while lowering risk and predict that one day multidrug immunotherapy will become the standard of care for newly diagnosed type 1 diabetes.
Similar(55)
This approach may feasibly enhance efficacy to the point that survival gains may become worthwhile.
Studies of other cleansing agents have suggested that split-dose regimens may further enhance efficacy.
Combined therapy associating anti-angiogenesis with inhibition of ILK1 may significantly enhance efficacy.
Cross-stage immunity elicited by blood-stage parasites may further enhance efficacy of this immunization regimen.
Non-lamellar-forming lysolipids and fatty acids, some of which may be designed to be prodrugs, can be created by phospholipase action in diseased tissues thereby providing for targeted drug release and proliferation of molecular entities with conical shape that break down the permeability barrier of the target cells and may hence enhance efficacy.
Sustained release rates, for instance, may enhance antitumour efficacy through an enhanced permeability and retention effect, via a better utilisation of the vascular abnormalities of solid tumours, eventually leading to a greater tumoural uptake (Maeda, 2001).
Related(20)
may augment efficacy
may optimize efficacy
may enhance performance
may enhance efficiency
may enhance impact
may enhance therapeutic
may enhance effective
may define efficacy
may enhance longevity
may lose efficacy
may enhance altruism
may increase efficacy
may reflect efficacy
may enhance diabetes
may overstate efficacy
may add efficacy
may enhance decision
may enhance susceptibility
may have efficacy
may improve efficacy
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