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The use of 0.25% may increase efficacy.
Pharmacodynamic separation by intermittent delivery of epidermal growth factor receptor tyrosine kinase inhibitors with chemotherapy may increase efficacy by overcoming hypothesized antagonism.
In China, some studies have reported that traditional Chinese medicinal herbs (TCMHs) may increase efficacy and reduce toxicity when combined with EGFR-TKI, but outside of China few studies of this kind have been attempted.
Small molecule inhibitors designed to target signaling pathways regulating stem cell renewal and maintenance may increase efficacy of traditional therapies.
Tamoxifen dose escalation not only may increase efficacy, but may also increase toxicity.
Thus, combinations of biologics and phototherapy may increase efficacy but are limited by adherence to therapy and concerns regarding the potential for skin cancer formation.
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These results suggest that CB3717 may be a useful new therapeutic agent in human primary liver cell carcinoma and that blocking the salvage pathway may further increase efficacy.
A fourth booster dose being given to participants at 18 months of age in the ongoing study might also bolster vaccine efficacy, notes Vasee Moorthy, the lead person for malaria vaccines at WHO. "A really important point is we don't know what's going to happen with the booster dose," he says, adding that it may even increase efficacy rates in the younger group.
Continuous infusion of β-lactam antibiotics commonly increases the time that the antibiotic concentration exceeds its MIC and may therefore increase efficacy.
Therefore, the combination of an AKT inhibitor with 5-FU may potentially increase efficacy of 5-FU treatment in colorectal cancer patients.
Many of the chemotherapeutic drugs are potently cytotoxic to neoplastic and normal cells, although newer targeted therapies developed against specific cancer phenotypes may potentially increase efficacy and decrease toxic side effects [ 6].
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