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The existence of a third MMP homolog in Tribolium and in other insects may directly correlate with the need for a sophistically regulated degradation of a more complex extracellular matrix.

An initial trial in patients with metastatic cRCC introduced the hypothesis that maximal COX-2 immunostaining may directly correlate with response to the combination (Rini et al, 2006).

CXCR4 was the predominant biomarker on pan-cytokeratin+ cells in the circulation of patients with metastatic RCC, suggesting that the presence of CXCR4 expression on these cells may directly correlate with metastatic RCC.

Since the EqSO4b cell line contains higher copy numbers of viral genome and oncoprotein transcripts than the EqSO1a [ 33], it is possible that the observed decreased level of MGMT protein found may directly correlate with BPV oncogene expression levels and be due to a similar mechanisms induced by BPV E5/E7 oncoproteins.

These bidirectional effects were in agreement with the changes observed in Akt activity as well as in its downstream target BAD in the lipid rafts of the two cell types, which may directly correlate with the cell-type-dependent pro-apoptotic or anti-apoptotic effect of aPPD.

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Addressing other features in need of clarification: A) While transverse breaks in the platinum along ESCRT-III filaments at ∼4 nm intervals are reproducible (and distinct from the 5.5 nm breaks seen along actin), they are a result of platinum decoration and may or may not directly correlate to a structural feature of the underlying filament.

These findings indicate that the roles of STAT3 in both CD4 T cells and B cells may be complex, and may not directly correlate with the functions of IL-6 and IL-21.

Issues of validity arise because reported PT behaviour may not directly correlate with their real practice.

It is known that the total level of Gli2 may not directly correlate with its enrichment at the cilia tips.

In other words, importance in an internet-based network may not directly correlate to importance in a stakeholder network.

It is important to note, however, that the relative abundance of GLUT mRNAs in the LV may not directly correlate with the relative abundance of GLUT protein.

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