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Also, infectious agents may directly modulate GR functioning [36].
In glaciated mountainous terrains, glacial erosion may directly modulate tectonic deformation by resetting the orogenic topography and thereby providing an additional compensatory uplift mechanism.
Although less well established, there is also evidence that APP may directly modulate intracellular calcium homeostasis.
Similarly, several studies have suggested that APP may directly modulate calcium homeostasis independently of Aβ production [29], [30], [31].
SUMO may directly modulate Ras1 function since Ras1 was found in our proteomic analysis and confirmed as a sumoylation substrate in our bacterial sumoylation assay.
Our data strongly suggests that the early evolution of obesity-induced elevation of nocturnal FFA may directly modulate GSIS in the pancreas and/or indirectly reduce hepatic insulin clearance, either mechanism serving as a potential hyperinsulinemic compensatory signal.
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Alternatively, PIAS4 may directly regulate JMJD1A, and the study of the ability of PIAS4 to modulate epigenetic histone modifications via JMJD1A will be of interest.
Computational analysis indicates that >30% of protein-coding genes may be directly modulated by miRNAs.
It also implies that the gut microbiome may be directly modulated for the benefit of the host organism.
For example, cleavage kinetics may be directly modulated by modifying either the protease (PR) on the PC or the protease's cognate cleavage sequence (CS) on the TC.
Dynacortin, in contrast, may act downstream of the signaling networks to directly modulate the viscoelasticity of the actin network thereby promoting polarization in response to chemotactic stimulation.
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