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These differences may derive mainly from patient selection bias.
The occurrence of mtMSI may derive mainly from erroneous replication, whereas point mutations may be attributed to oxidative damage caused by reactive oxygen species.
However, the accumulation of NFTs within neurons, composed largely of ubiquitin and the microtubule-associated protein tau, is another important hallmark of AD. 1 While the accumulation of Aβ may derive mainly from the failure of the clearance system as mentioned above, that of NFTs appears to be associated at least partially with the failure of the ubiquitin-proteasome system.
Although no hard evidence favoring this assumption are available, it would be useful to examine the possibility that the S100A12 in serum of CD patients may derive mainly from neutrophils migrating through the blood vessels into the diseased ileum or that ileal inflammation triggers a more "systemic" type of response.
These trials respond to the realisation of high and growing HIV incidence among women, particularly in developing countries [ 13], and that existing prevention strategies, such as condom use and partner reduction, are not feasible for many women, whose risk may derive mainly from male partner behaviour [ 14, 15].
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This may further explain the finding of Margolin et al. [ 31] that the effect of CYP2D6 seems to derive mainly from premenopausal patients.
9–– 12 19 Contradictory findings derive mainly from studies in developing countries.
Radial dikes beneath Mt. Fuji mainly develop in a northwest southeast alignment, which may derive from collision between the Izu Peninsula on the Philippine Sea Plate and the North American Plate (Nakamura 1977; Ida 2009).
Third, the unequal number of studies from Asian countries, with data derived mainly from Japan, China, and Korea may have also been a source of bias.
A possible association of red meat intake with endometrial cancer risk may reflect a role of haem iron, which derives mainly from red meat and which has greater bioavailability than inorganic iron (Huang, 2003).
Leptin in cord blood is derived mainly from fetal adipose tissue, although the placenta may contribute, and correlates with birth weight and adipose tissue mass [ 22- 24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com