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It may cause cardiac contusion, rupture, cardiac valve dysfunction, and aortic laceration [1].
Kawasaki disease (KD) is a type of febrile self-limiting systemic vasculitis, which affects the coronary arteries (CA) and may cause cardiac ischemia during childhood and adult life.
To add even more pressure, Merck's second-best seller, the arthritis pill Vioxx, is suffering on fears that it may cause cardiac side effects in very rare cases.
The high plasma concentrations of adrenaline also may cause cardiac arrhythmias (irregularities in the heart rate and rhythm), electrocardiographic changes (in 27 percent of cases) and cardiac arrest (in 3 percent of cases) may occur rapidly after the onset of hemorrhage.
In the chronic state, high blood glucose induced by the effect of impaired glucose tolerance (IGT), especially postprandial hyperglycemia, may cause cardiac damage and dysfunction or apoptosis, eventually lead to the development of heart failure [5], [6].
Finally, TKI-induced changes to the thyroid function may cause cardiac toxicity.
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Furthermore, PTRF mutations may also cause cardiac dysfunction accompanied by cardiomyocyte hypertrophy and cardiac fibrosis [10].
IV administration may also cause cardiac and respiratory problems not seen with intramuscular injections [ 2, 16] and is best employed where good medical support is readily available [ 7].
For example, Type D has been related to poor adherence to continuous positive airway pressure therapy in patients with obstructive sleep apnea [ 41], which, in turn, may cause disturbed cardiac repolarization that can induce cardiac arrhythmias in these patients [ 42].
Prediction of 'torsadogenicity' (the likelihood of a compound initiating TdP) is of high relevance for cardiac safety assessment because, if it occurs, TdP often degenerates into ventricular arrhythmias that may cause sudden cardiac death (unless self-terminated; see Figure 1).
But recent research suggests that both may cause occasional cardiac problems.
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