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Considering that Cthrc1 does not affect osteoclastogenesis, enhanced bone formation by overexpression of Cthrc1 may attenuate bone loss caused by enhanced osteoclastic bone resorption induced by OVX.

Although BMD increases with PTH occur even in the presence of potent antiresorptive agents such as alendronate [ 163], antecedent oral bisphosphonates started concurrently with PTH may attenuate bone mass improvement seen with PTH [ 164, 165].

Programs incorporating high intensity PRT alone are also particularly effective for improving muscle strength, mass and size [ 10] and may attenuate bone loss if they incorporate targeted hip and spine loading exercises [ 11, 12].

14 Bisphosphonates, which inhibit bone resorption, increase trabecular bone thickness, and may attenuate bone marrow lesions and knee pain, 15 supporting the hypothesis that increased subchondral bone turnover may contribute to OA pain.

In combination with previous studies suggesting TC may attenuate bone loss in elderly women, and research in older adults suggesting that TC may reduce fall-related fracture risk by improving postural control and preventing falls [ 6, 7], our results affirm the value of a future, more definitive trial of TC for fracture prevention in osteopenic women.

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In cancer patients with early stage disease, denosumab can attenuate bone loss from antihormonal treatments, and in prostate cancer, may reduce disease progression.

The long-term objective of our research will be to determine whether CD44 expression and that of its transcriptional targets may be predictive for those breast cancer patients at higher risk of developing skeletal disease and/or may potentially lead to the development of novel and more effective therapeutic strategies to attenuate bone metastasis.

Inhibition of its biological functions can attenuate bone destruction in RA [ 9].

The long-term objective of our research will be to determine whether CD44 expression and that of its transcriptional targets may be predictive for those breast cancer patients at higher risk of developing skeletal disease and/or potentially lead to the development of novel and more effective therapeutic strategies to attenuate bone metastasis.

Categorical variable are described with frequency count followed by percentages.. TC tended to attenuate bone loss at all sites measured.

The enlargement of the tibial plateau bone may attenuate the tibial cartilage, and this attenuation may play a role in the pathogenesis of OA [ 15].

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