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The induction of VEGF expression by miR-146a may affect angiogenesis and inflammation during OA pathogenesis.

As a speculation, this oxidative stress may then contribute to the proinflammatory environment of diabetes and may affect angiogenesis.

In addition to a direct effect of the chemokines on these functions, they may affect angiogenesis indirectly by inducing the recruitment of monocytes to the tumors.

Furthermore, NHERF2 may affect angiogenesis as well, as we have shown that the polygonal network formation of NHERF2 depleted cells in Matrigel was inhibited.

These data suggest that TR, an inhibitor of SOD-1, may affect angiogenesis and raise the possibility for the use of TR as therapy in pathologies in which neovascularisation is involved, including neoplasia.

Interestingly, we have recently demonstrated a role for αB-crystallin in regulating chronic inflammatory processes, suggesting an additional path through which αB-crystallin expression may affect angiogenesis during pathological conditions.

Similar(54)

In addition, Cre activity in Tie2-Cre mice, as well as being present in endothelial cells, is also apparent in approximately 80% of hematopoietic cells [34], [35], and it is tempting to speculate that the haploinsufficiency or deletion of Rac1 in this compartment may well affect angiogenesis.

Alterations in the activity of SOD-1 may therefore affect angiogenesis and angiogenesis-dependent pathologies.

The fact that S100A4 induces remodeling of the ECM suggests that the protein may also affect angiogenesis [ 21].

As polyamines are essential for proliferation of endothelial cells (Morrison et al, 1995), their decreased synthesis may also affect angiogenesis.

Thus, TNFA and IL6 may affect placental angiogenesis locally, that is, in a paracrine manner.

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