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In particular, the maximum response after oral administration, measured as pain relief after 2 h, is approximately 70% in clinical trials [9], and up to 40% of attacks fail to respond to a particular drug [10].
This was done by plotting each patch in the region according to its maximum response after airflow on and off (Fig. 6G I).
To compare the absolute amplitudes of the response to airflow on and off between the patches recorded from the α' lobes of g0050-Gal4; UAS-G-CaMP and c305a-Gal4; UAS-G-CaMP flies, we plotted each patch according to its maximum response after airflow on and off (Fig. 8F; for the distribution of the patch area see Fig. S9).
Figure 1 shows the maximum response after pazopanib treatment.
We compared the baseline-firing rate and the amplitude of the receptive field (=the maximum response after baseline subtraction) for all 100 cells in both attentional conditions with the same measures in the fixation condition.
Several phase III clinical trials suggested that if the patient obtains a maximum response after 3 6 months of first-line treatment, he/she can switch to maintenance therapy [ 5, 6, 15].
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Maximum responses after airflow on and off (MaxOn and MaxOff) for each patch were calculated in the same manner as the maximum airflow on and off responses of the calyces and lobes.
Maintenance therapy is the continued use of less potent and toxic drugs when the maximum response stabilizes after a defined period of first-line treatment, such that the patient would have a prolonged PFS, few adverse effects (AEs), delayed recurrence of tumor-associated symptoms, and, consequently, an improved QoL.
An average of 60% of patients who receive conventional radiotherapy attain GH and IGF-1 normalization, but the maximum response is seen after 10 15 years [ 24, 33].
For positive timing experiments, we observed diverse changes in the spiking responses measured at non-paired positions as spiking elicited at positions directly adjacent to the paired position (±1) increased in some neurons but decreased in others, and the position eliciting the maximum response often changed after pairing.
In routine clinical practice, patients with high tumor burden and symptomatic disease may be candidates for maintenance (immediate) therapy, whereas asymptomatic patients are often given a 'drug holiday' after achieving maximum response, followed by second-line (delayed) treatment after progression [ 22– 25].
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Justyna Jupowicz-Kozak
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