The CVD regimen induced time-dependent apoptosis in the A375 cells, with a maximal response at ∼20% after 72 h.
The MSS grades of canines with mild IVDD in both the control group and experimental group indicated that treatment reversed the effects of IVDD and that the canines exhibited maximal response to treatment after 2 weeks, P > 0.05).
In general, there was a progressive increase in the amount of neutralization after each successive DNA vaccination (data not shown) with maximal response at 1 week after the 3rd DNA immunization, with highest and most consistent levels in the trivalent vaccine group delivered with the Agro-Jet® device.
Previous experimental data indicate that 0.5 ng/ml (20 pM) of TGF-β is sufficient to yield a maximal response of Smad phosphorylation after 1 hour TGF-β treatment [27], [28].
High levels of disease were achieved as early as day 2 postinjection with maximal response by day 6, after which the disease resolved to almost normal by day 20.
There is now conclusive evidence that tumor response to chemotherapy and radiation requires time, and that some tumors achieve a maximal response only after several months.
The earliest time-point at which hypertrophy is detectible in rats is 24 hours after insult, reaching maximal response in 3 4 days; the human response is further delayed with detection and maximum around 4 days and 2 3 weeks, respectively [44].
Time to maximal response on CO was 2 minutes after the end of the infusion.
After obtaining the maximal response to PHE (10-5M), the response curves to fenoldopam, a D1 receptor agonist [ 9, 10], were measured by a cumulative concentration-dependent protocol (10-9 to 10-5M).
Maximal response in tumour Ktrans occurred at 26 h after starting the CYT997 infusion in patient 25, whereas in all other cases maximal responses were at 6 days.
Every attack can't create a maximal response, because it feeds the enemy".
