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Exact(6)

Both strands had a modulus of elasticity that ranged from 185 to 205 GPa, a minimum elongation of 3.5%, and a maximum relaxation of 2.5%.

Given this threshold, docking conformations can be filtered or flagged if they exceed a threshold of 4 kcal/mol with a maximum relaxation of 0.4 Å as they are unlikely to have high binding affinity.

We found a clear dose-dependent vasodilation with a maximum relaxation of 92 ± 4% for ZDL rats at a concentration of 10-4 mol/L ACh.

The N. sativa extract induced concentration-dependent relaxation in aortic rings precontracted by PE and KCl with a maximum relaxation of 62.3 ± 1.9%EC50=8.5 8.5 mg/mL) and 60.2 ± 1.2%EC50=7.6 7.6 mg/mL), respectively and 1(b)).

Vessels from STZ-treated, diabetic animals showed a similar difference, conduit arteries responding with a maximum relaxation of 88±9%9% (n = 9) compared with 46±10%0% (n = 9, p < 0.05) in resistance arteries.

In patients with CAD, endothelial function, measured as the maximum relaxation of saphenous veins to calcium ionophore A23187, was significantly greater in the 2007 compared to the 2003 group (44 ± 15% vs 28 ± 12%, P < 0.001, n = 36 each; Fig. 2d).

Similar(54)

Maximum relaxation responses of aortic and pulmonary artery rings were decreased in the MCT-vehicle group (54.80±5.69 and 35.87±4.78, respectively) compared to the control (91.51±4.79 and 54.32±2.39, respectively) but improved with LASSBio-965 treatment (50 mg/kg; 88.43±4.54 and 59.36±4.83, respectively).

The magnitude of maximum relaxation, however, was not affected.

The maximum relaxation reached was 71±6%6% of the phenylephrine-induced vasoconstriction.

The endothelial integrity was verified with the appropriate molar concentration of acetylcholine that produces 100% of the maximum relaxation response (EC100) in each experimental group (acetylcholine EC100 = 1.0  μmol/L for control rat carotid or acetylcholine EC100 = 100  μmol/L for diabetic rat carotid), over phenylephrine-induced precontraction [ 8, 9].

The EC50 was defined as the concentration of N. sativa that induced 50% of the maximum relaxation from the contraction elicited by PE (10−6 M) or KCl (6 × 10−2 M) and was calculated from the concentration-response curve, analyzed by nonlinear regression (curve fit) using GraphPad Prism (Version 4.0).

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