Sentence examples for maximum concentration tmax from inspiring English sources

Relative to the IR formulation, the time to reach the maximum concentration (tmax) was delayed with the MR formulation from 1.3 to 8.7 h with the 10 mg dose and to 6.2 h with the 30 mg dose.

In addition, absorption rate constant (Ka), elimination rate constant (Kel), absorption half-life (T1/2a), elimination half-life (T1/2el), and time of maximum concentration (Tmax) were not significantly different between the diabetic patients and controls (p > 0.05).

Experimental BE data [median time to reach the maximum concentration (Tmax) = 20 h and low clearance = 0.192 L/h) indicated a decrease and then an increase in the intrasubject variability [root mean square error (RMSE)] for truncated AUC as a function of time.

As pharmacokinetic parameters, changes in plasma drug concentration following administration (Cp), maximum plasma concentration (Cmax), time to maximum concentration (Tmax), plasma unbound fraction value (fu), and the presence of active metabolites were collected from clinical trial data obtained from Japanese subjects.

In particular, upon removal of the epidural catheter, drug effectiveness, half-life (T1/2), and time to maximum concentration (Tmax) must be assessed: as a general rule, the recommendation is made to wait at least 2 half-lives before removal, resuming pharmacological prophylaxis after 8 h (period required for clot formation) minus Tmax.

It has been suggested that the onset of the effect of triptans is related to the systemic drug-transfer rate[10], thus parameters expressing drug transfer and binding rates (A cp, A Ф 1B, A Ф 1D ) were calculated by using (Eq. 3, 4, 5), where the maximum plasma concentration was Cmax, and the time to maximum concentration Tmax and the maximum occupancy were Фmax1B and Фmax1D, respectively.

The maximum concentration (Cmax) was the maximum observed plasma concentration of PTX, and the time-to-the-maximum concentration (Tmax) was the time corresponding to Cmax.

Vd/F; apparent volume of distribution, t1/2(a); absorption half life, t1/2; elimination half life, CLtot/F; total body clearance, Cmax; maximum serum concentration, Tmax; time to maximum concentration, AUC; area under the curve, MRT; mean residence time (AUMC/AUC).

AUC0 12h, area under the plasma concentration-time profile from time of first dose (time zero) to 12 hours after first dose; Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration.

The PK parameters, Cmax (maximum plasma concentration), Tmax (time of maximum plasma concentration), kelim (terminal elimination rate constant), t½ (half-life) and AUC (area under the concentration vs time curve) were derived from the blood [H]-PG545 or plasma PG545 concentration vs time data using model independent methods.

Abbreviations are: n, number; Geomean, geometric mean; Min, minimum; Max, maximum; Cmax, the observed maximum plasma concentration; tmax, time to reach Cmax; AUC, area under the curve; λz, apparent first-order rate constant; t1/2, apparent terminal half-life associated with negative terminal slope; CL, total body clearance of drug from plasma; Vss, volume of distribution at steady state.